Restitution slope is principally determined by steady-state action potential duration
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منابع مشابه
Restitution slope is principally determined by steady-state action potential duration
Aims The steepness of the action potential duration (APD) restitution curve and local tissue refractoriness are both thought to play important roles in arrhythmogenesis. Despite this, there has been little recognition of the apparent association between steady-state APD and the slope of the restitution curve. The objective of this study was to test the hypothesis that restitution slope is deter...
متن کاملRestitution slope is determined by the steady state action potential duration: law and disorder.
Sex in basic research: concepts in the cardiovascular field R. Ventura-Clapier, E. Dworatzek, U. Seeland, G. Kararigas, J.-F. Arnal, S. Brunelleschi, T. C. Carpenter, J. Erdmann, F. Franconi, E. Giannetta, M. Glezerman, S. M. Hofmann, C. Junien, M. Katai, K. Kublickiene, I. R. König, G. Majdic, W. Malorni, C. Mieth, V. M. Miller, R. M. Reynolds, H. Shimokawa, C. Tannenbaum, A. M. D’Ursi, and V....
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. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391–6. . Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 1999;100:1660–6. . Breithardt G, Cain ME, El-Sheri...
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OBJECTIVES We undertook this study to determine whether human atrial fibrillation (AF) relates to steeply sloped action potential duration restitution (APDR) kinetics and whether the spatial nonuniformity of APDR promotes persistence of AF. BACKGROUND A steeply sloped APDR curve is known to be an important determinant of the induction of more complex action potential duration (APD) dynamics a...
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Transgenic mice have been increasingly utilized to investigate the molecular mechanisms of cardiac arrhythmias, yet the rate dependence of the murine action potential duration and the electrical restitution curve (ERC) remain undefined. In the present study, 21 isolated, Langendorff-perfused, and atrioventricular node-ablated mouse hearts were studied. Left ventricular and left atrial action po...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2017
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvx063